Which of the following are common pharmacologic treatments for AUB?

• A. Antibiotics and antivirals
• B. Chemotherapy agents
• C. Estrogens, progestins, oral contraceptives, NSAIDs, and antifibrinolytic drugs
• D. Antidepressants only

Answer: (C)

When abnormal uterine bleeding is treated pharmacologically, the goal is to control the endometrium and reduce blood loss using hormonal therapies and agents that affect hemostasis. The best approach here includes estrogens and progestins to regulate endometrial growth and shedding, combined oral contraceptives to provide predictable cycles and lessen heavy bleeding, NSAIDs to reduce menstrual blood loss and relieve pain by lowering prostaglandin production, and antifibrinolytic drugs to prevent clots from breaking down, thereby diminishing bleeding.

Antibiotics and antivirals target infections and aren’t standard treatments for AUB unless there’s a concurrent infectious cause. Chemotherapy agents are used for cancer, not for AUB. Antidepressants don’t address the bleeding mechanism and aren’t used as primary therapy for AUB.